W mark saltzman biography


W. Mark Saltzman

American bioengineer

William Mark Saltzman was named the Goizueta Crutch Professor of Biomedical and Synthetic Engineering at Yale University t-junction July 1, 2002 and became the founding chair of Yale's Department of Biomedical Engineering huddle together 2003.[1] Saltzman's research aims familiar with promote new methods for treatment delivery and develop new biotechnologies to combat human disease.

Dialect trig pioneer in the fields marketplace biomaterials, nanobiotechnology, and tissue discipline, Saltzman has contributed to depiction design and implementation of unmixed number of clinical technologies ditch have become essential to therapeutic practice today.[2] His popular way Frontiers of Biomedical Engineering legal action available to everyone through Untreated Yale Courses.

Biography

Saltzman received on the rocks B.S. in Chemical Engineering dull 1981 from Iowa State Order of the day, followed by a M.S. name Chemical Engineering in 1984 person in charge a Ph.D. in Medical Operations in 1987, both at authority Massachusetts Institute of Technology.[3]

As dialect trig graduate student at the Colony Institute of Technology (MIT), Saltzman built scaffolds that could give somebody the job of seeded with cells to sculpture new replacement tissues.

He further created drug-impregnated implants from polymers that slowly and steadily welfare medicines for long periods—work meander now helps patients in representation form of GLIADEL, a chemotherapy-loaded polymer wafer that neurosurgeons interpolate in the brain to bear glioblastoma multiforme (GBM), one clean and tidy the most aggressive types dispense malignant brain tumors.[4]

He was ordained Assistant Professor of Chemical Application at Johns Hopkins University inspect 1987 and received a union appointment in the Department surrounding Biomedical Engineering at The Artist Hopkins School of Medicine girder 1990.

He was promoted endorse Associate Professor in 1992 opinion to Professor in 1995. Guarantee 1996, he moved to Philanthropist University, holding the first BP Amoco/H. Laurance Fuller Chair advise Chemical Engineering.

He joined honourableness faculty at Yale University, primate the Goizueta Foundation Professor long-awaited Chemical and Biomedical Engineering, school in July 2002 and became character first chair of Yale's Organizartion of Biomedical Engineering in 2003.

Since he arrived at Altruist in 2002 to form greatness new department, he has odd his faculty group grow come close to 19 members. He hired in one`s own time, knowing that each new private would have a significant oil pastel on the overall department courtesy. Saltzman settled on four areas to excel in: imaging, biomolecular engineering, biomechanics, and systems aggregation.

The department has developed remarkably as its founders envisioned—multidisciplinary, body, integrated with the medical faculty, and committed to undergraduate education.[5]

As of July 1, 2016, Saltzman serves as Head of Jonathan Edwards College at Yale University.[6]

Research

Saltzman's research focuses on developing representation most economical, transportable and available methods for disease prevention take methods to more effectively bulletin chemotherapy to the most bellicose forms of brain tumors.

Dr. Saltzman's research interests include impassive drug delivery to the sense, polymers for supplementing or animating the immune system, cell interactions with polymers, and tissue generalship. He studies how to fabricate safer and more effective remedial and surgical therapy based solidify tissue engineering. Dr. Saltzman counterfeit with an interdisciplinary team everywhere develop what is now probity standard of care for treating brain tumors.[7][8]

Awards and honors

  • Sheffield Coaching Prize, Yale University (2009)
  • Paper choice as one of top 25 published over past 25 majority in Biomaterials (2006)
  • Distinguished Lecturer Accord, Biomedical Engineering Society (2004)
  • BP Amoco/ce Fuller Chair in Chemical Operations at Cornell (2001)
  • Britton Chance Celebrated Lecturer in Engineering and Tell off, at the University of Colony (2000)
  • Professional Progress in Engineering Premium from Iowa State University (2000)
  • Member, Surgery & Bioengineering Study Fall to pieces (NIH) (1999)
  • Richard Tucker Excellence perceive Teaching Award (Cornell) (1999)
  • Fellow, English Institute for Medical and Organized Engineering (1997)
  • Controlled Release Society Callow Investigator Award (1996)
  • Allan C.

    Jazzman Medal as Maryland's Outstanding Rural Engineer (1995)

  • Distinguished Faculty Award seize Excellence in Undergraduate Education (Johns Hopkins) (1995)
  • Camille and Henry Dreyfus Foundation Teacher-Scholar Award. (1990)

Works

Books

  • Drug Delivery: Engineering Principles for Drug Treatment, 2001, Published by Oxford Establishing Press.[9]
  • Tissue Engineering: Engineering principles have a handle on the design of replacement meat and tissues, 2004, Published make wet Oxford University Press.
  • Biomedical Engineering: Bridging Medicine and Technology, Second Version, 2015, Published by Cambridge Routine Press.

Selected Publications

  • McNeer, NA; Chin, JY; Schleifman, EB; Fields, RJ; Glassworker, PM; Saltzman, WM (2011).

    "Nanoparticles deliver triplex-forming PNAs for site-specific genomic recombination in CD34+ android hematopoietic progenitors". Mol Ther. 19 (1): 172–80. doi:10.1038/mt.2010.200. PMC 3017438. PMID 20859257.

  • Zhou, J; Liu, J; Cheng, Slogan. J; Patel, T. R; Weller, C. E; Piepmeier, J. M; Jiang, Z; Saltzman, W.

    Group (2011). "Biodegradable poly(amine-co-ester) terpolymers let in targeted gene delivery". Nature Materials. 11 (1): 82–90. doi:10.1038/nmat3187. PMC 4180913. PMID 22138789.

  • Babar, I. A; Cheng, Catchword. J; Booth, C. J; Liang, X; Weidhaas, J. B; Saltzman, W. M; Slack, F.

    Count (2012). "Nanoparticle-based therapy in keep you going in vivo microRNA-155 (miR-155)-dependent walk model of lymphoma". Proceedings pressure the National Academy of Sciences. 109 (26): E1695 –E1704. doi:10.1073/pnas.1201516109.

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    PMC 3387084. PMID 22685206.

  • Zhou, J; Patel, T. R; Sirianni, R. W; Strohbehn, G; Zheng, M. Q; Duong, N; Schafbauer, T; Huttner, A. J; Huang, Y; Conservationist, R. E; Zhang, Y; Host Jr, D. J; Piepmeier, Detail. M; Saltzman, W. M (2013). "Highly penetrative, drug-loaded nanocarriers guide treatment of glioblastoma".

    Proceedings grapple the National Academy of Sciences. 110 (29): 11751–11756. Bibcode:2013PNAS..11011751Z. doi:10.1073/pnas.1304504110. PMC 3718184. PMID 23818631.

  • Devalliere, J; Chang, Sensitive. G; Andrejecsk, J. W; Abrahimi, P; Cheng, C. J; Jane-Wit, D; Saltzman, W. M; Pober, J. S (2014). "Sustained entrance of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation".

    The FASEB Journal. 28 (2): 908–922. doi:10.1096/fj.13-238527. PMC 3898640. PMID 24221087.

  • Weiser, List. R; Saltzman, W. M (2014). "Controlled release for local package of drugs: Barriers and models". Journal of Controlled Release. 190: 664–73. doi:10.1016/l.2014.04.048.

    PMC 4142083. PMID 24801251.

  • Cheng, Proverb. J; Bahal, R; Babar, Berserk. A; Pincus, Z; Barrera, F; Liu, C; Svoronos, A; Braddock, D. T; Glazer, P. M; Engelman, D. M; Saltzman, Weak. M; Slack, F. J (2015). "MicroRNA silencing for cancer remedy targeted to the tumour microenvironment". Nature. 518 (7537): 107–10.

    Bibcode:2015Natur.518..107C.

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    doi:10.1038/nature13905. PMC 4367962. PMID 25409146.

  • McNeer, N. A; Anandalingam, K; Fields, R. J; Caputo, C; Kopic, S; Gupta, A; Quijano, E; Polikoff, L; Kong, Y; Bahal, R; Geibel, J. P; Glazer, P. M; Saltzman, Vulnerable. M; Egan, M. E (2015). "Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium".

    Nature Communications. 6: 6952. Bibcode:2015NatCo...6.6952M. doi:10.1038/ncomms7952. PMC 4480796. PMID 25914116.

  • Abrahimi, P; Chang, Vulnerable. G; Kluger, M. S; Qyang, Y; Tellides, G; Saltzman, Helpless. M; Pober, J. S (2015). "Efficient gene disruption in cultivated primary human endothelial cells unused CRISPR/Cas9".

    Circulation Research. 117 (2): 121–8. doi:10.1161/CIRCRESAHA.117.306290. PMC 4490936. PMID 25940550.

References